Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir.

Special Seminar Assistant Professor

Research interests: Asymmetric catalysis for organic synthesis, including chiral diaminocarbene ligands and VHOIɅDVVHPEOHGGLQXFOHDU catalysts; development of VPDOOPROHFXOHDQWLɅFDQFHU agents; and total synthesis of complex molecules with interesting biological activities. Abstract Novel chiral Co-salen catalysts capable of self-assembly through hydrogen bonding have been developed. First, a self...

Hydrogen bonding and alcohol effects in asymmetric hypervalent iodine catalysis: enantioselective oxidative dearomatization of phenols.

Asymmetric catalysis at the mesoscale: gold nanoclusters embedded in chiral self-assembled monolayer as heterogeneous catalyst for asymmetric reactions.

Research to develop highly versatile, chiral, heterogeneous catalysts for asymmetric organic transformations, without quenching the catalytic reactivity, has met with limited success. While chiral supramolecular structures, connected by weak bonds, are highly active for homogeneous asymmetric catalysis, their application in heterogeneous catalysis is rare. In this work, asymmetric catalyst was ...

Hydrogen-bond-directed enantioselective decarboxylative Mannich reaction of β-ketoacids with ketimines: application to the synthesis of anti-HIV drug DPC 083.

The decarboxylative Mannich reaction (DMR) of b-ketoacids with imines has emerged as a very important tool for the synthesis of natural products and biologically active compounds. The elegant work of Robinson on the total synthesis of ( )-tropinone represents the first practical example of utilizing the DMR as a key step in organic synthesis. Herbert and co-workers and Mangla and Bhakuni then d...

Non-traditional hydrogen bond explanation of asymmetric catalysis of Mukaiyama aldol reactions by dinuclear zinc semi-crown ligands